Factor associated with neutral sphingomyelinase activation

Expression Go to the top of the page Help. See details. Bibliography Go to the top of the page Help. Related articles in PubMed New variant identified in major susceptibility locus to tuberculosis on chromosomal region 8qq13 in Moroccan population: a case control study.

Qrafli M, et al. Biol Chem, Dec. Zhang Y, et al. Cytogenet Cell Genet, Forsberg J, et al. Biochem Biophys Res Commun, May PMID Regulation of neutral sphingomyelinase-2 nSMase2 by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells. Clarke CJ, et al. Mol Pharmacol, Oct. Title: Caspase-2 associates with FAN through direct interaction and overlapping functionality. Title: New variant identified in major susceptibility locus to tuberculosis on chromosomal region 8qq13 in Moroccan population: a case control study.

Title: Regulation of neutral sphingomyelinase-2 nSMase2 by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells.

Title: Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase. Title: Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor.

Phenotypes Go to the top of the page Help. GeneReviews: Not available. Variation Go to the top of the page Help. Pathways from PubChem Go to the top of the page. Interactions Go to the top of the page Help. General gene information Go to the top of the page Help. Inferred from Electronic Annotation more info. Traceable Author Statement more info. General protein information Go to the top of the page Help. Explain These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build.

Isoform 2 has a longer N-terminus, compared to isoform 1. Explain This section includes genomic Reference Sequences RefSeqs from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds contigs from both reference and alternate assemblies.

By fluorescence in situ hybridization, Zhang et al. Adam-Klages et al. The authors noted that FAN-mediated generation of ceramide may activate the c-Raf-1 signaling cascade Segui et al. Neutrophil recruitment was also reduced after intraperitoneal stimulation.

However, mice lacking Fan showed no increased susceptibility to Listeria, Toxoplasma, or Streptococcus pathogens. Specific antibody responses were impaired in mutant mice, associated with reduced splenic leukocyte numbers. Montfort et al. Adam-Klages, S. Cell , Montfort, A. Segui, B. Zhang, Y. Cell Genet. NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine.

While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions. Printed: Jan. To ensure long-term funding for the OMIM project, we have diversified our revenue stream. We are determined to keep this website freely accessible. Unfortunately, it is not free to produce. Expert curators review the literature and organize it to facilitate your work.

Please join your colleagues by making a donation now and again in the future. Donations are an important component of our efforts to ensure long-term funding to provide you the information that you need at your fingertips.